Search on: SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS 
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Descriptor English:   Suppressor of Cytokine Signaling Proteins 
Descriptor Spanish:   Proteínas Supresoras de la Señalización de Citocinas 
Descriptor Portuguese:   Proteínas Supressoras da Sinalização de Citocinas 
Synonyms English:   SOCS Proteins
Suppressors of Cytokine Signaling Proteins  
Tree Number:   D12.644.360.024.374
D12.776.157.057.249
D12.776.476.024.437
Definition English:   A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box. 
History Note English:   2006 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50800 
Unique Identifier:   D050826 

Occurrence in VHL:
 

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